Amino Acid Sequences for Human Urinary Bikunin (Trypsin Inhibitor) Isomers.
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چکیده
منابع مشابه
Amino acid sequences involving the histidine residues of porcine trypsin.
is identical with that found in the region of the active center of bovine trypsin, which includes histidine-29 and histidine-46, except that a serine residue (asterisk) replaces a tyrosine residue in the bovine enzyme. The sequence of one of the two other histidine-containing peptides bears some similarity to the sequence surrounding histidine-79 of bovine trypsin. The lack of structural homolo...
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Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely (and sometimes experiencely) used as a supportive drug for patients with inflammatory disorders such as pancreatitis, shock, and disseminated intravascular coagulation (DIC). Also, previous in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties at sites of inflammation...
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Introduction Urinary trypsin inhibitor, a serine protease inhibitor, has been widely used, particularly in Japan, as a drug for patients with acute inflammatory disorders such as pancreatitis, shock and disseminated intravascular coagulation. Previous in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil el...
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In the present study, a trypsin inhibitor was first extracted from lung cancer tissue and purified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A final yield of 20 to 60 micrograms of inhibitor with a specific activity of 2040 units/mg of protein was obtained from 1 g of original lung cancer tissue. This inhibitor inhibited trypsin strongly, plasma kallikrein weakly, and plasmi...
متن کاملCharacterization of placental bikunin, a novel human serine protease inhibitor.
We reported previously the cloning of a novel human serine protease inhibitor containing two Kunitz-like domains, designated as placental bikunin, and the subsequent purification of a natural counterpart from human placental tissue (Marlor, C. W., Delaria, K. A., Davis, G., Muller, D. K., Greve, J. M., and Tamburini, P. P. (1997) J. Biol. Chem. 272, 12202-12208). In this report, the 170 residue...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1995
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.18.1599